Abstract
Juvenile xanthogranuloma is a rare benign non-Langerhans cell histiocytosis. Clinical manifestation usually occurs up to the age of 2 years, with yellowish papules and variable clinical progression. Approximately 0.75% of patients had systemic involvement and 0.25%, ocular alterations. The purpose of this report is to describe a case of a preschool 2-year-old female patient, with nodules in the upper right eyelid, 0.5-cm wide, with well-defined edges, an uncertain date of onset, a stable growth for 6 months, with no [...]
Highlights
Juvenile xanthogranuloma (JXG) is a proliferative disease included in the group of non-Langerhans histiocytosis (NLH) that mostly affects infants and children, and it is congenital in 40 to 70% of cases.(1)
Immunohistochemistry is usually negative for S-100 and positive for CD68, factor XIIIa and anti-CD4,(4) a fact that helps differentiating JXG from other Langerhans cell histiocytosis.(3)
The definitive diagnosis of JXG is histopathological. It shows a diffuse histiocytic infiltrate, with five distinct cell types, foamy macrophages and Touton giant cells, characteristic of JXG and present in about 85% of cases.(5) It is not an encapsulated lesion.(6) Immunohistochemistry is usually reactive for CD68, factor XIIIa and anti-CD4 markers.(7)
Summary
Pedro Henrique Oliveira Ribeiro[1 ], Laura Nagy Fritsch[2 ], Geraldo José Medeiros Fernandes[3 ], Adriano Macedo de Oliveira[4 ], Flávia Beatriz de Andrade Oliveira Ribeiro[5]. How to cite: Ribeiro PH, Fritsch LN, Fernandes GJ, Oliveira AM, Ribeiro FB. Upper eyelid juvenile xanthogranuloma: a case report. Descritores: Histiocitose de células não Langerhans; Xantogranuloma juvenil; Histiocitose; Neoplasias palpebrais. Corresponding author: Pedro Henrique Oliveira Ribeiro Rua Juscelino Barbosa, 885, Apartamento 501. Conflict of interest: There is no conflict of interest. Financial support: There is no financial support to this article
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