Abstract
In the present study, a phytochemical of Ficus sycomorus (Moraceae family) was screened, and the effect of this extract on rabbit performance indices, immunity, and carcass quality measures was determined. Ficus sycomorus samples were collected, air-dried, and extracted with 70% methanol to prepare a solution of 100 mg/mL concentration. The extract was subjected to high-resolution mass spectrometric measurements via ultra-high performance liquid chromatography-quadrupole time-of-flight-nanospray mass spectrometry (UPLC-QToF-MS) and 1H NMR analysis. Forty-eight male rabbits, one-month-old, belonging to the Blanc de Bouscat and New Zealand White breeds were selected and distributed equally in a 2 × 3 factorial trial. The rabbits within each breed received F. sycomorus extract at the dose of 0, 100, and 200 mg/kg for 60 days. Blood samples were collected and serum obtained for the detection of liver enzymes, serum lipids, and proteins. The results of UPLC-QToF-MS and molecular networking analysis revealed the presence of procyanidin B2, procyanidin A1, genistein, eriodyctiol, catechin, luteolin, biochanin A, and chlorogenic acid that might exhibit various pharmaceutical activities. However, the F. sycomorus extract reduced rabbit performance indices and carcass quality measures. In addition, this extract significantly depressed the low-density lipoprotein and triglycerides, which may indicate the antidyslipidemia effect of this extract on rabbits.
Highlights
Ficus sycomorus (F. sycomorus) is one of the ancient trees belonging to the family Moraceae
We investigated the molecular networking of F. sycomorus in this study
The major compounds present in the methanolic extract of F. sycomorus stem bark are listed in Table 2, and their molecular networking is illustrated in Figure 1, Supplementary Figures S1 and S2
Summary
Ficus sycomorus (F. sycomorus) is one of the ancient trees belonging to the family Moraceae. This fruit tree, a native of Africa, is widely distributed in the Mediterranean basin of Egypt. The Moraceae family consists of approximately 40 genera and over 1000 species of flowering plants, most of which are widely distributed in tropical and subtropical regions [1]. The. F. sycomorus contains numerous bioactive chemical ingredients, predominantly alkaloids, tannins, flavonoids, and phenolic compounds [2,3]. F. sycomorus contains numerous bioactive chemical ingredients, predominantly alkaloids, tannins, flavonoids, and phenolic compounds [2,3] These bioactive compounds are found in the fruits, leaves, and bark of the tree. A detailed investigation is required to understand the useful properties of this plant [2,4,5]
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