Abstract
Cancer is one of the most occurring diseases in developed and developing countries. Plant-based compounds are still researched for their anticancer activity and for their quantity in plants. Therefore, the modern chromatographic methods are applied to quantify them in plants, for example, UPLC-MS/MS (ultraperformance liquid chromatography tandem mass spectrometry). Therefore, the aim of the present study was to evaluate the content of sanguinarine, berberine, protopine, and chelidonine in Dicentra spectabilis (L.) Lem., Fumaria officinalis L., Glaucium flavum Crantz, Corydalis cava L., Berberis thunbergii DC., Meconopsis cambrica (L.) Vig., Mahonia aquifolium (Pursh) Nutt., Macleaya cordata Willd., and Chelidonium majus L. For the first time, N,N-dimethyl-hernovine was identified in M. cambrica, B. thunbergii, M. aquifolium, C. cava, G. flavum, and C. majus; methyl-hernovine was identified in G. flavum; columbamine was identified in B. thunbergii; and methyl-corypalmine, chelidonine, and sanguinarine were identified in F. officinalis L. The richest source of protopine among all the examined species was M. cordata (5463.64 ± 26.3 μg/g). The highest amounts of chelidonine and sanguinarine were found in C. majus (51,040.0 ± 1.8 μg/g and 7925.8 ± 3.3 μg/g, resp.), while B. thunbergi contained the highest amount of berberine (6358.4 ± 4.2 μg/g).
Highlights
Different ethnic communities of the world have used plant-based drugs to manage various ailments for centuries
0.80 the analytical methods used, because extracts from C. cava and F. officinalis were not analyzed by UPLC-MS/MS method earlier
These differences may result from Levels (μg/g)
Summary
Different ethnic communities of the world have used plant-based drugs to manage various ailments for centuries. Natural sources of drugs, such as paclitaxel (Taxus brevifolia) and Vinca alkaloids, are examples for the value of traditionally used plants for modern drug development. Plant-based molecules are used very often as drug precursors being converted into drugs by chemical modification, for example, 10-deacetybaccatin. It is established that about 120 plantderived compounds are used in western medicine, and about. 80% of the world population use medicinal plants in primary health care. Despite the fact that a lot of progress has been made towards the discovery of effective anticancer drugs, many western communities still use the plant-based drugs, including plants from traditional Chinese medicine. The plant-based drugs are used in developed and developing countries separately or together with synthetic drugs [1]
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