Abstract
Kudiezi injection (KDZI), also known as Diemailing injection, is a traditional Chinese medicine injection of the composite plant Ixeris sonchifolia Hance (also known as Kudiezi), and has been widely used to treat coronary heart disease, angina pectoris, and cerebral infarction, but its pharmacological mechanisms remain unclear. This study is designed to explore the effects of KDZI on middle cerebral artery occlusion and reperfusion (MCAO/R) rats, and to identify metabolic features of cerebral ischemia reperfusion by using a nontargeted metabolic profiling method based on ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). In this process, 32 potential biomarkers were found in plasma. KDZI significantly upregulated the levels of taurochenodesoxycholic acid, leucine, l-phenylalanine, l-tryptophan, arachidonic acid (ARA), and phosphatidyl ethanolamines (PE), phosphatidyl cholines (PC) and downregulated the levels of l-valine and 5-hydroxyindole-3-acetic acid (5-HIAA) in plasma. The results indicated that the mechanisms of KDZI on MCAO/R were related to the mechanisms of amino acid and lipid metabolism.
Highlights
IntroductionThe process of aging has hastened the increasing number of elderly people in human society
The process of aging has hastened the increasing number of elderly people in human society.In the meantime, the risk of cerebrovascular disease increases year by year
Hematoxylin and eosin (HE) staining (Figure 1A) showed that no neuronal damage or inflammatory cell infiltration was observed in the cerebral cortex of rats in Sham group, the number and morphology cells were normal, and the cell membrane and nucleolus3 of were clear
Summary
The process of aging has hastened the increasing number of elderly people in human society. The risk of cerebrovascular disease increases year by year. The increasing morbidity and mortality of cerebral ischemia seriously affects the physical and mental health of the elderly, as well as an unbearable financial toll for both society and families [2]. When ischemic cerebrovascular disease attacks, the priority goal is to recover the blood supply of the brain as soon as possible to avoid brain tissue necrosis. If the treatment is not timely, cerebral ischemia reperfusion injury will occur. Ischemic cerebrovascular patients should be evaluated rapidly in the early phase to receive timely and appropriate treatment
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