Abstract
BackgroundThe purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.MethodsTwenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis.ResultsThere were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14).ConclusionsUphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.
Highlights
The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans
Achilles tendinopathy refers to a clinical condition characterized by activity-related Achilles tendon pain associated with focal tendon tenderness and intratendinous imaging changes
The aim of this study was to build upon these previous studies and investigate whether uphill treadmill running at a higher (15o) incline and speed creates histopathological changes within the rat Achilles tendon consistent with Achilles tendinosis in humans
Summary
The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans. Functioning to transmit the muscle contractile forces necessary for human stance and locomotion, the Achilles tendon must be able to withstand large-magnitude tensile loads. Structurally designed to withstand these loads, injuries of the Achilles tendon thought to result from repetitive loading are common [1,2,3,4,5]. The most common of these injuries is termed Achilles tendinopathy (tendo– = tendon, –pathy = disease). Achilles tendinopathy refers to a clinical condition characterized by activity-related Achilles tendon pain associated with focal tendon tenderness and intratendinous imaging changes.
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