Abstract
Recently, Up-frameshift protein 1 (UPF1) is reported to be downregulated in various cancers and its low expression is closely correlated with poor prognosis. UPF1 is well known as a master regulator of nonsense-mediated mRNA decay (NMD), which serves as a highly conserved mRNA surveillance process protecting cells from aberrant toxic transcripts. Due to dysfunction of UPF1, NMD fails to proceed, which contributes to tumor initiation and progression. This review shows a brief summary of the aberrant expression, functional roles and molecular mechanisms of UPF1 during tumorigenesis. Increasing evidence has indicated that UPF1 could serve as a potential biomarker for cancer diagnosis and treatment for future clinical applications in cancer.
Highlights
We summarize recent studies on the role of Up-frameshift protein 1 (UPF1) in cancers, including those focused on its aberrant expression, biological functions, and associated clinical features, in addition to its regulatory network, and further debate the prognostic and therapeutic values of UPF1 in human cancers
Cao et al [33] reported that UPF1 level was downregulated in 160 lung adenocarcinoma (LADC) tissues compared with matched adjacent normal tissues, a recent study uncovered by Han and colleagues focused on the biological role of UPF1 in LADC, and confirmed an inconsistently obvious upregulation of UPF1 in LADC cells [34]
Several researches showed that UPF1 was significantly downregulated and acted as a tumor suppressor in most types of cancer including hepatocellular cancer (HCC), gastric cancer (GC), thyroid cancer (TC), ovarian cancer (OC) and glioma
Summary
Several researches have reported that UPF1 act as tumor suppressor and was downregulated in various cancers. UPF1 downregulation has been consistently revealed in a great diversity of other tumor types, including hepatocellular cancer (HCC) [23, 25,26,27], gastric cancer (GC) [32], inflammatory myofibroblastic tumors (IMT) [36], thyroid cancer (TC) [37], ovarian cancer (OC) [38] and glioma [39]. These studies demonstrated that UPF1 has a tumor-suppressive role. Maybe the contributors to dysregulated expression of UPF1 in cancers are various, including tumor cell, pathological type and so on, which still need further investigations
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
