Abstract
AbstractIt is believed that the hypothalamus is the regulating center for blood glucose levels, but how chronic stress leads to hyperglycemia is not known. In this experiment, we use the chronic immobilization stressed rat as a model, and found that only rats with increased expression of GAD65 in the amygdala have an elevated level of blood glucose. Considering there are fiber tracks between the amygdala and hypothalamus, including GABAergic projections, this result suggests that the changes in GAD65 expression in the amygdala may correlate with the changes in blood glucose levels, and point to the importance of the the amygdala in blood glucose regulation.
Highlights
Type 2 diabetes is a common disease, but its pathogenesis is not clear till
The results primarily suggest that there may be correlation between the change of GAD65 expression in the amygdala and the change of blood glucose levels
The expression of GAD65 of chronic immobilization stress (CIS) group was significantly higher in rats with elevated blood glucose (p < 0.05), while it was not significant different among rats without elevated blood glucose (p > 0.05)
Summary
Type 2 diabetes is a common disease, but its pathogenesis is not clear till now. Modern medical research has revealed that people have a higher incidence of hyperglycemia and type 2 diabetes (Surwit et al, 1992, Karen et al, 2001) under chronic stress. Hypothalamus is the regulating center of the blood glucose, which has two different glucose-sensing neurons, including glucose-inhibited neurons and glucose-excited neurons. They participate in the regulation of homeostasis of blood sugar (Rory et al, 2006), and possibly regulate the releasing concentration of GABA by controlling the opening and closing state of KATP channel, thereby affecting the transmission of blood glucose information (Chan et al, 2007). There is a wide range of fiber tracks between amygdala and hypothalamus, including GABAergic projection. It is not yet clear whether changes of GABA in amygdala correlate with rising of the blood glucose. The results primarily suggest that there may be correlation between the change of GAD65 expression in the amygdala and the change of blood glucose levels
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
