Abstract
In August 2021, the American Academy of Pediatrics published a guideline, the first of its kind, to synthesize decades of research on the care of febrile neonates. The guideline is not meant to dictate one particular course of treatment for every clinical scenario, but rather to provide evidence-based recommendations to guide care in collaboration with the patient's caretaker(s). The guideline considers evolving bacteriology, costs of care, advances in laboratory testing and inflammatory markers, and known risks related to the hospitalization of young infants. The guideline highlights 21 key action statements to guide practitioners in the care of neonates presenting with fever, with the aim of optimizing outcomes while reducing risk and unnecessary costs. [Pediatr Ann. 2022;51(2):e49-e51.].
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