Abstract
The use of medical ozone in the treatment of chronic pain is progressively expanding in Spain and today it is used both in public and private medical centers. However, there is a great lack of knowledge about this technology not only in primary care but also in medical specialties. Although its biochemical bases are well determined and there are various systematic reviews and meta-analyses in the literature that justify its use in pain medicine, some professionals still are prejudiced against it. The evidence level of using medical ozone according SIGN (Scotish Intercollegiate Guideline Network) criteria is similar or superior to most of the techniques used in a Pain Unit. In this paper, we have done a review on ozone therapy in pain medicine, compiling the evidence published about it.
Highlights
Ozone therapy is the use of medical ozone as a therapeutic substance in pathologies with chronic hypoxia, inflammation, and redox imbalance in which ozone has proven to be effective (Baeza et al, 2015)
In addition to health professional associations that try to unify criteria and develop protocols of treatment, as well as training health professionals in the use of this substance, the Catholic University of Murcia has taken the initiative by creating a chair of Ozone Therapy and Chronic Pain to better promote training and researching inside the Spanish universities network
The results indicated that the technique was effective in the treatment of protrusions, the efficacy was not higher than that of the microdiscectomy, according to the authors’ experience (Buric, 2005)
Summary
Ozone therapy is the use of medical ozone as a therapeutic substance in pathologies with chronic hypoxia, inflammation, and redox imbalance in which ozone has proven to be effective (Baeza et al, 2015). In 2018 (Anzolin and Bertol, 2018; Costa et al, 2018; Raeissadat et al, 2018), 2019 (Arias-Vázquez et al, 2019; Noori-Zadeh et al, 2019) and 2020 (Sconza et al, 2020), six systematic reviews and meta-analyses were published in different journals supporting the use of ozone in knee osteoarthritis with a high level of evidence (GRADE 1+; Table 1) These studies do not compare the results according to the radiological status of the knee, and we think this is basic fact, because hyaluronic acid is not indicated for moderate or severe knee osteoarthritis. The interest in intradiscal or paravertebral medical ozone injections has special relevance, and the analgesic, anti-inflammatory, and muscle relaxant effects of the ozone
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