Abstract
Undifferentiated connective tissue diseases are an actually existing clinical disease state of unknown origin. They clinically resemble autoimmune diseases with the presence of a kind of autoantibody, which does not meet the diagnostic criteria for any defined connective tissue disease. Evolution is the most prominent feature of undifferentiated connective tissue diseases, of which, 30％ could evolve into connective tissue diseases, 70％ remain in the initial state. The severity of connective tissue diseases evolving from undifferentiated connective tissue diseases tends to be mild with low-grade major organ injury. Clinical manifestations and evolution process reveal that undifferentiated connective tissue diseases are an important member in the spectrum of autoimmune diseases. Key words: Undifferentiated connective tissue diseases; Connective tissue diseases
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