Abstract
BackgroundThis systematic review aimed to gather evidence from research on the current state of liquid biopsy in medical practice, specifically focusing on mutation detection and monitoring.MethodsA systematic search was performed via Medline.ResultsThe results of this investigation indicate that liquid biopsy plays a critical role in the detection and management of tumors. This technique gives healthcare providers the ability to gather critical and reliable information that may potentially shape the diagnosis, treatment, and prognosis of a variety of cancers in the near future. This study further reveals that liquid biopsy has several potential shortcomings that may limit its application and use in the healthcare setting. Nevertheless, liquid biopsy remains a valuable tool that is gradually becoming a part of routine healthcare practice in oncology departments and hospitals worldwide.ConclusionsThe evidence described herein reveals the potential relevance of liquid biopsy as an important prognostic, diagnostic, and theranostic tool. This non-invasive procedure enables healthcare practitioners to detect and monitor genomic alterations and will likely replace tumor tissue biopsy as the standard method for detecting and monitoring mutations in the future. The information obtained herein can enable physicians to make informed decisions regarding current treatment options; however, liquid biopsy has not yet been incorporated into routine clinical diagnostics for cancer patients.
Highlights
This systematic review aimed to gather evidence from research on the current state of liquid biopsy in medical practice, focusing on mutation detection and monitoring
It is worth noting that commonly used tissue biopsy methods, such as surgical biopsy, are invasive, and their effectiveness depends on the cancer stage and local area that is biopsied [11]
A total of 70 studies were used in this systematic review
Summary
This systematic review aimed to gather evidence from research on the current state of liquid biopsy in medical practice, focusing on mutation detection and monitoring. Physicians and researchers have regarded tissue biopsy as the gold standard for providing data that produces positive health outcomes among patients with a variety of cancers [6,7,8,9]. Non-invasive techniques, such as liquid biopsy, have emerged as viable options to help physicians manage different types of cancerous cells [11, 12]. Research on the effectiveness of these non-invasive techniques, including that of liquid biopsy, must be performed to determine their usefulness for the detection and monitoring of genomic alterations.
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