Abstract
Neutrophils are main players in the effector phase of the host defense against micro-organisms and have a major role in the innate immune response. Neutrophils show phenotypic heterogeneity and functional flexibility, which highlight their importance in regulation of immune function. However, neutrophils can play a dual role and besides their antimicrobial function, deregulation of neutrophils and their hyperactivity can lead to tissue damage in severe inflammation or trauma. Neutrophils also have an important role in the modulation of the immune system in response to severe injury and trauma. In this review we will provide an overview of the current understanding of neutrophil subpopulations and their function during and post-infection and discuss the possible mechanisms of immune modulation by neutrophils in severe inflammation.
Highlights
Update on Neutrophil Function in Severe InflammationAdcock 4,5, Sharon Mumby 5 and Leo Koenderman 6*
Neutrophils are polymorphonuclear and phagocytic leukocytes that comprise the first line of host immune response against invading pathogens [1]
We review here the roles and function of neutrophils in modulating the immune response during inflammation and summarize the mechanisms behind these processes
Summary
Adcock 4,5, Sharon Mumby 5 and Leo Koenderman 6*. Reviewed by: Veronique Witko-Sarsat, Institut National de la Santé et de la Recherche Médicale (INSERM), France Claudia Ida Brodskyn, Fundação Oswaldo Cruz (Fiocruz), Brazil. Specialty section: This article was submitted to Molecular Innate Immunity, a section of the journal
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