Abstract
Nanobiotechnology plays an important role in drug delivery, and various kinds of nanoparticles have demonstrated new properties, which may provide opportunities in clinical treatment. Nanoparticle-mediated drug delivery systems have been used in anti-inflammatory therapies. Diseases, such as inflammatory bowel disease, rheumatoid arthritis, and osteoarthritis have been widely impacted by the pathogenesis of inflammation. Efficient delivery of anti-inflammatory drugs can reduce medical dosage and improve therapeutic effect. In this review, we discuss nanoparticles with potential anti-inflammatory activity, and we present a future perspective regarding the application of nanomedicine in inflammatory diseases.
Highlights
The inflammatory response is a major pathogenic component in various diseases (Ferrero-Miliani et al, 2007)
Different nano-size materials have different physicochemical features, which allow NPs to reach their target tissue. Chronic inflammatory diseases, such as age-related macular denegation (AMD) and uveitis, require the drug to be maintained at a certain concentration, which is important in treatment
The results showed that Decoy ODN-loaded CSPLGA NS had potential to be an effective strategy for ulcerative colitis (UC) treatment
Summary
The inflammatory response is a major pathogenic component in various diseases (Ferrero-Miliani et al, 2007). Different nano-size materials have different physicochemical features, which allow NPs to reach their target tissue Chronic inflammatory diseases, such as age-related macular denegation (AMD) and uveitis, require the drug to be maintained at a certain concentration, which is important in treatment. Inflammation-related diseases are more plentiful than above Chronic diseases, such as IBD (Wu et al, 2019a), osteoarthritis (McMasters et al, 2017), rheumatoid arthritis (Shi et al, 2020b), and skin diseases, are treated with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or Glucocorticoids as major or auxiliary treatment options, and frequent or continuous anti-inflammatory treatment is needed. The synthesized NPs are used as carriers, and loaded with anti-inflammatory drugs to form a NPs-based drug delivery system
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