Abstract
Apolipoprotein E gene polymorphism may be associated with cerebral small vessel disease. Apolipoprotein E gene polymorphism may cause cerebral small vessel pathology (white matter lesions, lacunae, microbleeding, perivascular spaces, brain atrophy), through Aβ toxicity and Aβ related pathways, lipoprotein dysmetabolism, or destruction of neurovascular unit. Apolipoprotein E gene polymorphism may mediate the phenotypes overlap among cerebral small vessel disease, Alzheimer's disease and ischemic stroke, and may also mediate the heterogeneity of cerebral small vessel disease. Whether apolipoprotein E gene polymorphisms and related proteins can be used as therapeutic targets for cerebral small vessel disease remains to be investigated. Key words: Cerebral small vessel disease; Apolipoprotein E; Genotype
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