Update in Familial Cortical Myoclonic Tremor with Epilepsy

Abstract

Several names (“Cortical Tremor” = Crt Tr, Familial Adult Myoclonic Epilepsy = FAME, Benign Adult Familial Myoclonic Epilepsy = BAFME, Autosomal Dominant Cortical Myoclonus and Epilepsy = ADCME, Familial Cortical Myoclonic Tremor = FCMT, Familial Cortical Tremor with Epilepsy = FCTE, Familial Essential Myoclonus and Epilepsy = FEME, Familial Benign Myoclonus Epilepsy of Adult onset = FMEA, Heredofamilial Tremor and Epilepsy = THE) have been used to define a unique entity, Familial Myoclonic Cortical Tremor with Epilepsy (FCMTE), as proposed by van Rootselaar et al. (2005). All patients with FCMTE criteria share clinical and electrophysiological features. In contrast, Familial Infantile Myoclonic Epilepsy (FIME) and Adult-onset Myoclonic Epilepsy (AME) cannot yet be considered as FMCTE (Striano et al. 2009a).