Abstract
Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4+ T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease. This paper provides an update of the currently known HLA-DQ restricted gluten T cell epitopes with their names and sequences.
Highlights
Celiac disease is caused by an abnormal intestinal T-cell response to cereal gluten proteins
This report provides an update of a listing of HLA-DQ-restricted epitopes recognized by CD4+ T cells of celiac disease patients as reported in 2012
The criteria used for epitope definition are unaltered from the first report, and we refer to this publication for details (Sollid et al 2012)
Summary
Celiac disease is caused by an abnormal intestinal T-cell response to cereal gluten proteins. This report provides an update of a listing of HLA-DQ-restricted epitopes recognized by CD4+ T cells of celiac disease patients as reported in 2012. The criteria used for epitope definition are unaltered from the first report, and we refer to this publication for details (Sollid et al 2012).
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