UP1306: A Composition Containing Standardized Extracts of Acacia catechu and Morus alba for Arthritis Management.

Mesfin Yimam,Ping Jiao,Laura Wright,Lidia Brownell,Mei Hong,Teresa Horm,Qi Jia

doi:10.3390/nu11020272

Mesfin Yimam, Ping Jiao + Show 5 more

Open Access

https://doi.org/10.3390/nu11020272

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Journal: Nutrients	Publication Date: Jan 26, 2019
Citations: 6	License type: CC BY 4.0

Affiliation: State Street (United States), Fred Hutch Cancer Center

Abstract

Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of Acacia catechu and the root bark of Morus alba, could potentially be considered as a dietary supplement product for the management of arthritis.

Highlights

Osteoarthritis (OA) is characterized by progressive articular cartilage degradation that will lead to joint pain, immobility, and other functional impairments [1]
1, rats treated with and UP1306 showed statistically significant suppression arthritis severity from severity day 13 andscores continued this significance for the duration of 1.6 the study
In the current study, substantiating the effects on paw swelling, paw thickness, arthritis severity, pro-inflammatory cytokines, and matrix degrading enzymes, rats treated with UP1306 showed significantly reduced levels of uCTX-II. These findings indicate that cartilage protection activity is one of the primary functions of UP1306 suggesting its usage in management of arthritic conditions

Summary

Introduction

Osteoarthritis (OA) is characterized by progressive articular cartilage degradation that will lead to joint pain, immobility, and other functional impairments [1]. The current approach mainly targets to relieve symptoms by reduction of pain and improvement of joint function using oral or topical over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs). This strategy is known to mask the primary cause leading to irreversible damage to the articular structure. Chronic uses of NSAIDs for symptomatic relief of OA are limited due to their gastrointestinal, renal, and cardiovascular side effects [3]. These unmet needs could be bridged with natural products

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