UP-02.092 Relationship of Insulin-Like Growth Factor (IGF) Binding Protein-3 (IGFBP-3) Gene Polymorphism with the Susceptibility to Development of Prostate Cancer and Influence on Serum Levels of IGF-I, and IGFBP-3

Abstract

The insulin-like growth factor (IGF) axis plays a critical role in both the normal and cancer cell growth. IGF-I binds to the IGF-I receptor and begins a signaling cascade that regulates cell proliferation, apoptosis, and differentiation. The bioavailability of IGF-I is controlled by the binding protein, IGF binding protein-3 (IGFBP-3). In addition, IGFBP-3 is a strong anti-proliferative protein that provokes apoptosis and inhibits cell proliferation in prostate cancer. We conducted this study to investigate the association between insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) gene polymorphism and serum levels of IGF-I and IGFBP-3 and the incidence of prostate cancer (PCa) and benign prostatic hyperplasia (BPH).