Abstract
RATIONALE: Selective T helper (Th) 1 and Th2 type responses are induced following repeated topical exposure of BALB/c strain mice to chemical contact and respiratory allergens, respectively. Gene expression profiles following exposure of mice to the chemical respiratory allergen trimellitic anhydride (TMA) have been analyzed using oligonucleotide microarrays. The most strongly up-regulated gene was the T cell cytolytic molecule granzyme B. Changes in granzyme B expression in tissue isolated from mice treated with TMA, or with the contact allergen dinitrochlorobenzene (DNCB), have been measured using real time PCR.
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