UP-2.43: Nervous control of lower urinary tract (LUT) during detrusor overactivity (DO): an approach using modeled analysis of filling cystometries and pressure-flow studies

Abstract

DO is a frequent urodynamic diagnosis in patients with urge syndrome. DO is characterized by non inhibited detrusor contractions (NIDCs). The precise mechanism underlying DO remains discussed but evaluation of the detrusor excitation during NIDC and subsequent voiding could allow determining some ways of research. In the VBN model[1], the detrusor contraction depends on the excitation of the efferent neurons, quantified by their firing rate F or by F/Fmax[0-1]. Without DO, F/Fmax=0 during continence and in the range 0-1 during voiding, our objective was to apply the model to cystometries in order to analyze the efferent excitation.