Abstract
Luteinizing hormone (LH) secreted from the anterior pituitary, signals Leydig cells of the testes to produce testosterone. A common genetic variant of LH (vLH) has been identified. The prevalence of vLH allele has been estimated worldwide as a carrier frequency of 0% to 53% of Caucasians and is known to be more active than the wild-type protein. Screening for vLH has primarily relied on relative immunoreactoivity in variant-sensitive and insensitive assays. In addition, restriction fragment length polymorphism (RFLP) studies are largely been used to confirm immunoassay results.
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