UP-02.001 Distribution of Onabotulinumtoxin A in the Human Prostate after Transrectal Injection and Localization of the High-affinity Receptors for the Toxin

T Gorgal-Carvalho,J Silva,A Lima-Carneiro,J Jesus,I Ramos,S Carvalho-Barros,A Coelho,A Avelino,F Cruz,P Dinis

doi:10.1016/j.urology.2011.07.819

UP-02.001 Distribution of Onabotulinumtoxin A in the Human Prostate after Transrectal Injection and Localization of the High-affinity Receptors for the Toxin

T Gorgal-Carvalho, J Silva + Show 8 more

https://doi.org/10.1016/j.urology.2011.07.819

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Journal: Urology

Publication Date: Sep 1, 2011

Affiliation: Instituto de Biologia Molecular e Celular, University of Porto, Hospital de São João

#Synaptic Vesicle Protein 2 #Transrectal Injection + Show 8 more

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Abstract

Intraprostatic injection of onabotulinumtoxin A (onabotA) has been explored recently as a new treatment for LUTS due to BPE/BPH in patients who are refractory to medical treatment with poor surgical conditions. In this study we evaluate the distribution of the toxin injected in the gland through MRI imaging and describe the localization of synaptic vesicle protein 2 (SV2), the onabotA high-affinity receptor, in the human prostate.

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