Unwholesome heart (Hypercholesterolemia) and naturally available drugs: A comprehensive review

Abstract

Hypercholesterolemia is a common disorder in developed countries. It refers to abnormalities in lipid metabolism, plasma lipid transport, or a disorder in the synthesis and degradation of plasma lipoproteins which leads to a high level of fat in the blood. The utilization of natural medicines for the treatment of several diseases and disorders dates back to ancient times. A lot of herbal medicines have got their place on the world market as options to the prescribed drugs to manage and treat various ailments. Hypercholesterolemia contributes a lot to the manifestation and development of atherosclerosis and coronary heart disease (CHD). Hypercholesterolemia prevalence continued to increase annually, requiring the development of drugs capable of lowering blood lipids to check death rate and morbidity due to cardiovascular complications. The current review is designed to gather knowledge about the Management and treatment of hypercholesterolemia, using drugs from Natural sources as the cornerstone instrument. Although synthetic lipid-lowering drugs are useful in treating Hypercholesterolemia, there are several adverse effects. So the use of herbal drugs is eminent as the cornerstone tool, for mitigation, prevention, and treatment of Hypercholesterolemia to address the said ailment. This review aims to provide benefits from numerous lipid-lowering agents with minimal or no side effects from natural sources, where the naturally available drugs can be taken as a means of the normal routine diet without any specific care.