Abstract
The current coronavirus disease 2019 (COVID-19) outbreak is considered as one of the biggest public health challenges and medical emergencies of the century. A global health emergency demands an urgent development of rapid diagnostic tools and advanced therapeutics for the mitigation of COVID-19. To cope with the current crisis, nanotechnology offers a number of approaches based on abundance and versatile functioning. Despite major developments in early diagnostics and control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is still a need to find effective nanomaterials with low cost, high stability and easy use. Nanozymes are nanomaterials with innate enzyme-like characteristics and exhibit great potential for various biomedical applications such as disease diagnosis and anti-viral agents. Overall the potential and contribution of nanozymes in the fight against SARS-CoV-2 infection i.e., rapid detection, inhibition of the virus at various stages, and effective vaccine development strategies, is not fully explored. This paper discusses the utility and potential of nanozymes from the perspective of COVID-19. Moreover, future research directions and potential applications of nanozymes are highlighted to overcome the challenges related to early diagnosis and therapeutics development for the SARS-CoV-2. We anticipate the current perspective will play an effective role in the existing response to the COVID-19 crisis.
Highlights
In the 20th century, millions of deaths occurred due to three influenza pandemics [1].The first deadly pandemic named ‘Spanish flu’ occurred in 1918, which was caused byH1N1 influenza A strain
It is expected that nanozyme mediated/engineered aptamers could be useful in the development of effective and affordable therapeutics and prophylactic vaccines for SARS-CoV-2 and other infectious pathogens [84]
Nanotechnology is expected to play a critical role in the fight against COVID-19
Summary
In the 20th century, millions of deaths occurred due to three influenza pandemics [1]. Diagnosis and quarantine to cut off the source of infection are the most effective control strategies for disease outbreaks, including the COVID-19 pandemic [11,12]. Inspired by the unique characteristics of nanozymes, it is assumed they have the potential to overcome the challenges related to the early diagnosis and therapeutic developments for SARS-CoV-2 infections. According to the author’s knowledge, almost no efforts have been devoted to reviewing the vast potential of nanozymes to combat the COVID-19 infection In this perspective, we present a comprehensive study of recent updates on nanozymes and their possible applications for detection and treatment for the SARS-CoV-2.
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