Abstract
Graphical AbstractThe multifaceted roles of EV-miRNAs derived from MSCs in tumor progression and therapeutic applications. MSC-EVs can transfer miRNAs into tumor cells to regulate cell proliferation, invasion and metastasis, immune response, angiogenesis, and chemosensitivity as well. One or more of MSCs, EVs and miRNAs can be modified to achieve the inhibitory effect on tumor progression, which provides the promising approaches for tumor clinical treatment. Besides, miRNAs in EVs can also mediate the interaction between MSCs and tumor cells in the TME (Created with Biorender.com).
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