Unveiling the Impact of Homogenous Vaccines on Clinical Symptoms and Risk Factors Following the SARS-CoV-2 Infection

Abstract

Background: The COVID-19 pandemic is significant due to its global impact on public health and life situations. It has led to widespread infections and strained healthcare systems, causing significant loss of life. The pandemic has underscored the urgent need for effective measures to control its spread and protect communities worldwide. Objectives: The main goal of this research was to evaluate the clinical symptoms, risk factors, and manifestations linked to COVID-19 among the vaccinated healthcare worker (HCW) population under study. Materials and Methods: The study population comprised HCWs with respiratory symptoms who received three doses of vaccination homogeneously. Real-time polymerase chain reaction (RT-PCR) testing was conducted on nasopharyngeal and nasal swab samples using a one-step RT-PCR. The enzyme-linked immunosorbent assay also evaluated immunoglobulin G antibody levels. Results: Among the most commonly reported symptoms, general fatigue, fever, and cough were the most prevalent, divided by vaccine type. Furthermore, among the associated risk factors, concerns about transmission to other family members, anxiety, and depression were found to be prominent. Conclusion: The study findings highlight that the vaccine type is associated with clinical manifestations. Additionally, the result reveals the significant contribution of occupational roles to the experiences of HCWs during the COVID-19 pandemic. The findings emphasize the need for tailored support systems to address the diverse challenges faced by HCWs, such as concerns about transmission, anxiety, and occupational stress.