Unveiling the Enigmatic Plasmodium knowlesi: Insights, Challenges, and Promises in Malaria Research

Abstract

Plasmodium knowlesi, a malaria parasite found in southeast Asia, can infect both primates and humans, potentially causing severe malaria. It is closely related to Plasmodium vivax, and its treatment utilizes chloroquine or artemisinin combination therapy. Plasmodium knowlesi presents significant health and economic challenges due to its zoonotic nature. However, it also serves as a valuable model for scientific research, aiding in vaccine development and understanding malaria invasion mechanisms. Its use facilitates progress in pharmaceutical investigations and the establishment of in vitro culture methods with both primate and human cells.