Abstract
AbstractThe Brook rearrangement is a valuable synthetic tool that facilitates the controlled construction of complex molecules. Conventionally, it generates carbanion intermediates utilized in subsequent functionalization reactions. In this review, we will explore recent advancements in the Brook rearrangement that extend beyond the traditional functionalization reactions. Specifically, we will highlight its involvement in unusual bond cleavage, annulation reactions, and dearomatization efforts. The novelty of this rearrangement is underscored by showcasing its most recent applications.1 Introduction2 Novel Synthetic Pathways Involving the Brook Rearrangement2.1 C–C and C–X Bond Formation2.2 C–C and C–X Bond Cleavage2.3 Stereodefined Substituted Silyl Enol and Allenol Ethers2.4 Annulation Reactions2.5 Dearomatization3 Synthetic Applications4 Conclusion
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