Unveiling In situ fibrillation for superior tissue scaffolds with two-phase copolymer microcellular foams

Abstract

High open-pore content and high mechanical strength are important in Tissue engineering. However, an increase in one property is often at the expense of the other. This study reports a first-of-its-kind study using two-phase copolymers Poly (caprolactone-co-lactic acid) (PLCL) as a compatibilizer, combining in-situ fibrillation and microcellular foaming, thus preparing foams with high open-pore content and high mechanical properties. The porous foam scaffold promotes the adhesion and diffusion of endothelial cells and expedites scaffold endothelialization. Additionally, the enhanced open porosity of the foams augments the effectiveness of drug absorption and release, underscoring its significant potential for practical application.