Abstract
We present the case of a 29-year-old female with a 2.5-month history of continuous fever, weight loss, vomiting, ataxia, tremors, altered consciousness, and motor deficits. Extensive investigations initially aimed at infectious aetiologies were unrevealing. However, the discovery of weakly positive anti- N-methyl-D-aspartate (NMDA) receptor antibodies in the cerebrospinal fluid (CSF) led to the diagnosis of anti-NMDA receptor encephalitis. The patient showed a positive response to immunomodulatory therapies but developed complex partial seizures and dyskinesias during the course of treatment. This case underscores the importance of considering autoimmune encephalitis in the differential diagnosis of refractory neurological symptoms, particularly when conventional investigations fail to yield a definitive diagnosis.
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