Abstract
BackgroundHand, food, and mouth disease (HFMD) is a highly contagious disease caused by enteroviruses infection. It is a health problem in young children under 5 years of age worldwide. The common causative agents are coxsackievirus A 16 (CA16) and enterovirus 71 (EV71). In recent years, coxsackievirus A6 (CA6) has emerged to be one of the major etiologic agents of HFMD worldwide including in Thailand.Case descriptionWe reported cases with unusual skin manifestations of CA6-associated HFMD such as widespread severe cutaneous eruption, large vesicles (varicelliform), purpuric-like lesions or Gianotti–Crosti like eruptions.Discussion and evaluationMolecular characterization of the CA6 strains from those patients found that all were clustered in the same group of CA6 that are currently circulating in Thailand.ConclusionsClinicians need to be aware of the expanded range of cutaneous findings in CA6-associated HFMD in order to properly consider the diagnosis, management and prevention.
Highlights
Clinicians need to be aware of the expanded range of cutaneous findings in coxsackievirus A6 (CA6)-associated HFMD in order to properly consider the diagnosis, management and prevention
Hand, food, and mouth disease (HFMD) is a highly contagious disease caused by enteroviruses infection
All seven of CA6 variants associated with atypical HFMD in Thailand in 2014 were investigated by phylogenetic relationship analysis, which was performed by comparing nucleotide sequences of the viral protein 1 (VP1) region with previously published sequences
Summary
Coxsackievirus A6 (CA6) has emerged to be one of the major etiologic agents of HFMD worldwide including in Thailand. Food, and mouth disease (HFMD) is a highly contagious disease caused by enteroviruses infection. It is a health problem in young children under 5 years of age worldwide. Coxsackievirus A6 (CA6) has emerged to be one of the major etiologic agent of HFMD worldwide including a large scale outbreak in Thailand (Puenpa et al 2013).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
