Abstract

Clear cell odontogenic carcinoma (CCOC) and hyalinizing clear cell carcinoma (HCCC) are rare malignancies that arise from different histologic origin. The histology is similar, and in some cases it is impossible to distinguish both lesions. We report an unusual presentation of well-defined nodular lesion affecting the maxillary gingival in a 19-year-old female patient presenting clinically as a benign or reactive-like lesion. Periapical radiography showed a discrete area of resorption of the alveolar bone. The patient was submitted to an excisional biopsy. The material was sent for histopathologic and immunohistochemical examination. The diagnosis was carcinoma with a clear cell pattern, and it is not possible to distinguish between CCOC and HCCC. In this study, clinicopathologic, histologic, and immunohistochemical features of CCOC and HCCC were discussed because the histologic diagnostic was challenging. Radical surgical treatment and rehabilitation were performed. The patient is under follow-up without signs of recurrence.

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