Abstract
Students in graduate drug metabolism courses are usually introduced to the basic reactions in which cytochrome P450 (CYP) enzyme forms alcohols and epoxides. However, in the field a practicing researcher encounters a wide variety of complex and amazing products formed from drugs and other xenobiotic chemicals, a repertoire which would never be produced in academic efforts. These reactions can be understood by applying the basic chemistry of the CYP and other enzyme systems in a careful, stepwise manner. We have reviewed the unusual CYP reactions in 2001 and 2007 and now focus on some unusual reactions that have been reported since then, including non-CYP oxidations and reductions plus some conjugations and mixtures of oxidation/conjugation. Keywords: cytochrome P450; drug metabolism; rearrangement; oxidations; conjugations; plants
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