Unusual mandibular metastasis of bladder cancer in a patient and two synchronous malignancies, bladder cancer and chronic lymphocytic leukemia, in an inguinal lymph node: A case report

Abstract

Metastatic lesions to the mandible are rare, comprising less than 1% of all malignancies. Breast, lung and colon cancer are the most common primary tumors with a mandibular mass as the initial presentation of metastatic disease. The following report describes an unusual case of a mandibular mass in a patient with recurrent bladder transitional cell carcinoma (TCC) with a past medical history of chronic lymphocytic leukemia (CLL), as well as the synchronous presence of both cancers during the evaluation of an inguinal enlarged lymph node. The sudden appearance of an isolated lesion in the head and neck region should always raise suspicion in a patient with a history of cancer that rarely metastasizes to this site. The co-existence of two malignancies in the same lymph node is extremely rare, and, to our knowledge, this is the first case of metastatic bladder cancer and CLL in the same lymph node.