Abstract
Lipoma has been recognized to be one of the most common soft-tissue tumors in the oral region. This case report presents a heretofore undescribed intraoral lesion that resembled mature lipoma but also featured multiple non-lipomatous dendritic cell nodules immunopositive for S-100 protein. We demonstrate histological and immunohistochemical evidence of cellular transitions between non-lipogenic S-100 protein-positive dendrocytes and adipocytes. Although it is likely that this tumor comprises part of the spectrum of what has been referred to in the literature as lipoma, the presence of S-100 protein-positive dendritic cells as an integral component is quite unique and worthy of reporting.
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