Abstract
Unusual histology in primary pulmonary synovial sarcoma: Pearls to avoid misdiagnosis
Highlights
Primary pulmonary synovial sarcoma is an aggressive tumor sharing common histologic features with soft tissue synovial sarcoma [1,2,3,4,5]
Metastases, and survival data did not differ from typical pulmonary synovial sarcoma (Hartel et al)
The presence of focal unusual histologic findings characteristic of more common epithelial and mesenchymal tumors may lead to misdiagnosis
Summary
Primary pulmonary synovial sarcoma is an aggressive tumor sharing common histologic features with soft tissue synovial sarcoma [1,2,3,4,5]. In t(x;18) negative cases, diagnosis must rely on histologic and immunophenotypic features. The differential diagnosis of primary pulmonary synovial sarcoma is challenging when histologic features unusual to synovial sarcoma, but common to other neoplasms are focally present. This challenge is compounded with negative t(x;18) findings. We evaluated 17 cases of primary pulmonary synovial sarcoma where unusual histology was present to bring awareness of atypical morphology in this entity
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