Unusual Cytogenetic Changes in Chronic Granulocytic Leukemia in Blast Crisis: Hyperdiploid and Two Ph′ Chromosomes.

Abstract

s1 May 1966Unusual Cytogenetic Changes in Chronic Granulocytic Leukemia in Blast Crisis: Hyperdiploid and Two Ph′ Chromosomes.William H. KnospeWilliam H. KnospeSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1165_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe only consistent cytogenetic abnormality heretofore described among the human leukemias has been the Ph′ chromosome of chronic granulocytic leukemia. Several previous reports have described hyperdiploid cell lines with two Ph1 chromosomes.Case 1, a 25-year-old man, developed chronic granulocytic leukemia after a 5-month illness. He responded poorly to busulfan, and his course was complicated by massive painful lymphadenopathy and blast crisis. A lymph node biopsy section was initially interpreted as reticulum cell sarcoma but later revised to infiltration by primitive granulocytes. The granulocytes had a clonal line of 52 chromosomes including two Ph′ chromosomes. Lymphocytes from blood and lymph... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1165-1165KeywordsBiopsyBloodChromosomesCytogeneticsGranulocytesLymphLymph nodesLymphocytesSarcoma Issue Published: 1 May 1966 PDF DownloadLoading ...