Unusual Carfilzomib Toxicity: Three Cases of Drug-induced Thrombotic Microangiopathy (TMA) after Treatment with High-dose weekly Carfilzomib, Cyclophosphamide, and Dexamethasone (wCCD)

Abstract

Drug-induced thrombotic microangiopathy (DITMA) is a recognized but uncommon complication of proteasome inhibitors. We present 3 novel cases of TMA observed on the MCRN003/MYX1 phase 2 clinical trial in multiple myeloma (MM) previously treated with 1-3 lines of therapy (NCT02597062).