Abstract
AbstractPathogenic strains of Bordetella bronchiseptica undergo phase changing under in vitro conditions. This is the irreversible loss of virulence factors. Adhesins are involved in these structures. They permit adhesion and colonization of bacteria to respiratory epitheliums. Phase III‐bacteria adhere as well as Phase I‐bacteria under in vitro conditions (cells of respiratory epithelium from guinea pigs).Four phase III‐strains of seven isogenic pairs adhere in a significant higher number per cell than phase I‐agents. These results are confirmed by results of investigations with phase III‐strains constructed throughout cultivation on several culture media. Phase III‐bacteria colonize in significant lower numbers under in vivo conditions in rabbits and guinea pigs. Purin auxotrophic mutant strains colonize less in guinea pigs than in rabbits. In vitro adhesion does not reflect the real bacteria‐host interaction between adhesin and receptor.
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