Abstract
Both, the flavonolignane silybin and the decapeptide antamanide, protect animals against the mushroom poison phalloidin from Amanita species. The X-ray structures of silybin and antamanide have been solved in previous studies. Here an attempt has been made to explain the antagonistic antihepatotoxic protection by similar chemical structure elements in the two compounds. It can be shown that two aromatic rings in a definite arrangement are essential for the attachment to the target structure of the liver cell membrane. Comparable pharmacological tests are discussed.
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