Abstract
Psoriasis is a common, chronic, systemic inflammatory skin disease, the etiology and pathogenesis is unclear. An untargeted high-throughput metabonomics method based on liquid chromatography coupled to mass spectrometry was applied to study the serum metabolic changes in psoriasis vulgaris patients, and to discover serum potential biomarkers for identification, diagnosis and exploring pathogenesis of psoriasis. The serum metabolic profiles from 150 subjects (75 psoriasis patients and 75 healthy controls) were acquired, the raw spectrometric data were processed by multivariate statistical analysis, and 44 potential biomarkers were screened out and identified. The potential biomarkers were mainly involved in glycerophospholipid metabolism, sphingolipid metabolism, arachidonic acid metabolism, bile acid biosynthesis, indicated the pathogenesis of psoriasis may be related to the disturbed metabolic pathways.
Highlights
Psoriasis is a common, chronic, systemic inflammatory skin disease, the incidence and prevalence of psoriasis is significantly varied in different population, the prevalence in adults range from 0.91% (United States) to 8.5% (Norway), affecting approximately 2% of the population [1,2,3]
The potential biomarkers were mainly involved in glycerophospholipid metabolism, sphingolipid metabolism, arachidonic acid metabolism, bile acid biosynthesis, indicated the pathogenesis of psoriasis may be related to the disturbed metabolic pathways
The metabonomics study based on UPLC/Q-TOF MS was applied to investigate the serum metabolic profiling of the psoriasis patients and healthy controls
Summary
Chronic, systemic inflammatory skin disease, the incidence and prevalence of psoriasis is significantly varied in different population, the prevalence in adults range from 0.91% (United States) to 8.5% (Norway), affecting approximately 2% of the population [1,2,3]. Psoriasis is considered a multisystem disease, the recent research results show it is associated with several comorbidities, such as inflammatory bowel disease, psychiatric disorders, metabolic syndrome and cardiovascular disease, as well as some new comorbidities in osteoporosis, obstructive sleep apnea and chronic obstructive pulmonary disease were reported in current literature [5]. Research on etiology and pathogenesis of psoriasis mostly focus on immunological mechanisms and signaling pathways, the molecular mechanisms of psoriasis have been elucidated, the evidences of the relationship between psoriasis and metabolic syndrome come from clinical analysis or epidemiological analysis [24,25,26], only several studies dedicate to explore the global metabolic profiling of psoriasis patients [27,28,29]. We used the ultra-performance liquid chromatography coupled with quadruple time of flight mass spectrometry (UPLC/Q-TOF MS) - based metabonomics strategy to investigate and compare the metabolic changes in the psoriasis vulgaris patients and healthy controls, as well as to discover the psoriasis biomarkers by identifying significantly changed metabolites
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