Abstract
AbstractThe unsupported nanoporous gold (AuNPore) is demonstrated to be an active and stable heterogeneous catalyst for chemoselective transfer hydrogenation of quinolines using bio‐renewable formic acid (HCO2H) as hydrogen source. The AuNPore‐catalyzed transfer hydrogenation of quinolines proceeded smoothly in the presence of low amounts of HCO2H at a relatively low temperature to produce the desired 1,2,3,4‐tetrahydroquinolines (py‐THQs) in good to excellent yields. Mechanistic studies revealed that the AuNPore‐catalyzed transfer hydrogenation of quinolines proceeded through a sequence of 1,4‐hydride addition, isomerization, and 1,2‐hydride addition. This operationally simple protocol offers a practical alternative to the currently known methods for chemoselective quinoline reduction.
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