Abstract
Purpose: Back pain is a heterogeneous disease with biological, physical, and psychosocial etiologies. As a result, the underlying combination of factors that drive pain (i.e. the pain phenotype) is difficult to identify in an individual and a specific cause of pain cannot be identified in 90% of those who seek care [1]. It is also not possible to predict which patients develop pain that will become chronic. The Osteoarthritis Initiative (OAI) is a longitudinal, observational study of knee health with 4,796 enrollees spanning 14 years with assessments of demographics, anthropometry, diet, physical activity, mental and physical health, medical history among other indices.
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