Unsteady targeted particle delivery in three-dimensional tortuous cerebral artery

Abstract

The present work investigates the complexities of unsteady targeted particle delivery in tortuous cerebral artery with three-dimensional twists and bends. Blood flow is modeled to mimic realistic pulsatile flow conditions along with its shear thinning behavior. One-way coupling is used to model particle flow. Dynamic particle release map (DPRM) for the targeted site, saccular aneurysm sac present in the artery, is determined on a chosen lumen cross section. Temporal variations in DPRM are analyzed and preferable catheter injection position and particle release pattern are recommended for minimum systemic toxicity.