Abstract
In this study, we explored the effects of unripe fruit extracts of Mangifera indica L. on the anti-aging activity in skin cells. Mangifera indica L. is a popular economical and medicinal plant with numerous health-beneficial properties. The aqueous extracts of unripe fruit of Mangifera indica L. were obtained and subjected to HPLC and NMR analyses for the identification of bioactive compounds. The anti-glycation effect of Mango unripe fruit extracts was monitored by in vitro model system of AGEs (Advanced glycation end products) formation. Mango unripe fruit extracts significantly inhibited the AGEs formation in a dose-dependent manner. Meanwhile, Mango unripe fruit extracts possessed a comparable efficiency to commercialized Kojic acids in the inhibition of melanogenesis in B16-F10 melanoma cells. The UVA-induced cell damages can be prevented and repaired by Mango unripe fruit extracts in skin fibroblast CCD-966SK. Compared to the untreated control, Mango unripe fruit extracts significantly increased the cell viability while being applied before (36%) or after (43%) UVA irradiation. These results verified the potential application of Mango unripe fruit extracts in the skin protection and recovery from UVA irradiation, as well as the suppression of AGEs formation and melanogenesis.
Highlights
IntroductionThe major polyphenolic compounds found in Mango fruit include quercetin, kaempferol, tannin, Chlorogenic acid, gallic acid, vanillic acid and mangiferin
We explored the effects of unripe fruit extracts of Mangifera indica L. on the anti-aging activity in skin cells
We examined the protective role of Mango unripe fruit extracts (MUE) against UVA irradiation on cells
Summary
The major polyphenolic compounds found in Mango fruit include quercetin, kaempferol, tannin, Chlorogenic acid, gallic acid, vanillic acid and mangiferin. Among these polyphenolics, mangiferin is a major bioactive constituent of M. indica. The AGEs formation is correlated to the melanin synthesis in melanocytes Since both AGEs and UV irradiation are involved in the skin pigmentation, there might be a functional correlation between these two factors. With these preliminary data, we provided useful information and further insights on the application of Mango fruit extracts in skin care
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
