Unresolved Problems in the Treatment of Arterial Hypertension and What to Do

Abstract

The emergence of numerous combinations of antihypertensive drugs in recent years creates a problem of choice for the doctor due to the lack of classification decisions in this area of hypertension.The objective: effectiveness study of the antihypertensive combination of enalapril and indapamide (Enzix duo and Enzix duo forte, manufacturer of Hemofarm AD, Serbia) was studied in patients with high cardiovascular risk of grade II with concomitant coronary heart disease or diabetes.Material and methods. Surveyed 28 patients randomized into 2 groups depending on the severity of the disease. To check the progress of the disease, a complex of surveys was conducted – the dynamics of clinical status, echocardiography, BP monitoring and questionnaires were studied using the 36-Hem Short-Form Health Survey (SF-36) classic questionnaire for self-assessment of quality of life.Results. The integrated assessment of the effectiveness of the applied treatment algorithm allowed us to establish a positive dynamics of the clinical condition of the patients, the achievement of the target blood pressure level in all studied patients (after adjusting the drug dose), a statistically significant decrease in the LVMH index and average BP monitoring values.Conclusions. The results of the study have shown that the drug combination therapy Enzix duo forte can successfully treat patients with any degree of hypertension, including patients with malignant forms, coronary heart disease, diabetes.