Abstract
To begin this commentary, it is appropriate to remember the 1959 statement made by Peyton Rous (Nobel Laureate in Physiology or Medicine 1966) that ‘‘A hypothesis is best known by its fruits. What have been those of the somatic mutation hypothesis? It has resulted in no good thing as concerns the cancer problem, but in much that is bad... Most serious of all the results of the somatic mutation hypothesis has been its effect on research workers. It acts as a tranquilizer on those who believe in it.’’ This statement was made over 50 years ago and well before the genetic study of cancer was put on steroids!
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