Unrelated Hematopoietic Cell Transplantation in Aplastic Anemia: There Is More to a Successful Outcome Than Meets the Eye.

Abstract

Aplastic anemia is a condition in which the hematopoietic stem cells fail to function adequately leading to peripheral pancytopenia. When the cytopenia is severe, patients require intensive support with blood products and broad spectrum antibiotics, and without definitive treatment, most will eventually die of infections or bleeding. Over the past 4 decades, however, these once uniformly fatal conditions have been transformed into potentially highly curable ones. Matchedrelatedhematopoieticcell transplantation(HCT) isnow the standard curativemodality for acquired severe aplastic anemia JAMA