Abstract
Dynamic rearrangements in the actin cytoskeleton underlie a wide range of cell behaviours, which in turn contribute to many aspects of human health including embryogenesis, cancer metastasis, wound healing, and inflammation. Precise control of the actin cytoskeleton requires the coordinated activity of a diverse set of different actin regulators. However, our current understanding of the actin cytoskeleton has focused on how individual actin regulatory pathways function in isolation from one another. Recently, competition has emerged as a means by which different actin assembly factors can influence each other's activity at the cellular level. Here such findings will be used to explore the possibility that competition within the actin cytoskeleton confers cellular plasticity and the ability to prioritise multiple conflicting stimuli.
Highlights
Introduction to the CompetitionCells interact with one another and their environment through precise control of their actin cytoskeleton
We have an appreciation of how these actin assembly factors and the varying actin networks they generate contribute to the formation of different cellular structures
Filopods are formed from parallel bundles of actin filaments with formins or Ena/VASP molecules at their tips [5,6,7]
Summary
Introduction to the CompetitionCells interact with one another and their environment through precise control of their actin cytoskeleton. Cells maintain a dynamic actin cytoskeleton by carefully balancing the activities of a diverse collection of actin regulators. Competition ensures cytoskeletal homeostasis and integration/coordination between the different actin regulatory pathways to support dynamic cell behaviour.
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