Abstract
Almost 35 years ago Jan and I discovered that factor VIII (FVIII) and von Willebrand factor (VWF) were intrinsically related. This feature led to the revelation of VWF as an essential hemostatic entity, deficient in von Willebrand's disease (VWD). We started in the late 1960s, working as PhD students independently of each other, Jan in 1968 on the characterization of FVIII at the ‘Haemophilia Clinic’ [1] and later the Paediatric Clinic of the University of Amsterdam, and I in September 1969 on the characterization of VWF at the Laboratory of Thrombosis and Haemostasis of the University Hospital in Utrecht, a laboratory headed by Dr Jan Sixma consisting of a small research lab and a diagnostic lab.
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